Nope. I’m pretty sure it’s not RUNNING your project that’s the issue, but the Editor itself. Try what they do in this link: OpenGL 4 Issues in Windows - Feedback & Requests - Epic Developer Community Forums
To create a shortcut to run the editor in opengl mode just create a copy if the UE4Editor-Cmd.exe ,right click and select properties, then under the shortcut tab edit the target line to follows:
Win64\UE4Editor-Cmd.exe -opengl4
Double click the shortcut once finished and the editor with boot with opengl enabled.