my item spawners, are on the correct settings and there are no mutator zones around, but whenever i drop an item, it despawns almost insatly and item spawners constantly desapwn, they dont keep the items, they just despawn and respawn and repeat, not sure why
I had the same issue and I fixed it by deleting some Item Spawners 
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I think there’s a limit of 100 items you can spawn on an island, any new item will despawn the oldest one.
Maybe using item placers and granters can act as a workaround ?