Will 100% CPU usage while you compiling shaders/build lighting kill CPU (i have Ryzen 5 3600 with stock cooler)
What do you mean by kill CPU? It will be taxed at 100% so anything else you’ll try to do will feel sluggish.
But if you have adequate cooling, it’s fine to run it at 100%. Check your temps, slap on an extra fan, open all windows, open the fridge…
If you approach / exceed the allowed max temp (95C for that CPU i believe), it will throttle down anyway.