If you are running out of room I would have a look at textures first. If you are setting the render to not stream textures it will load every texture along with all of their mips onto the GPU. That can potentially be a large resource hog. I think the Game Overrides has that set by default. Thats the first place I’d look if you are having memory issues.
There are some plugins that divide up views and such. Have a look on fab. I have not tried any myself so unfortunately I am unable to give you any guidance there.