Not sure if this will help anyone. For me the issue was the proximity sensor. Typically I test inputs without putting on the headset. At some point since the release of UE 5, Steam or Unreal began to default to only tracking and registering inputs when the headset is worn (VR Focus State=true). So I wasn’t seeing any inputs registering because the proximity sensor was returning false. I would maybe put on the headset for a second and notice that the controllers began tracking, but once you take off the headset the tracking is retained but the inputs don’t work.
Once I disabled Pause VR in Steam settings (as suggested by Rectus_SA) things started to work again.