Update:
I tried with 4.27 - same crashes.
I updated to 5.02 - same crashes.
I physically disconnected my monitor cable and plugged in again right after - runs for 10 minutes or so but gives me glitches and flickering on the screen. Then freezes again.
Unplugging and re-plugging again - same as above.
After 3 or 4 times unplugging and plugging in again it runs quite stable for a longer time and even glitches seem to go away.
I have the impression it is not a real crash but the monitor freezes.
When going to “quit immediately” I don’t see the usual red marked message that the program does not react anymore. Unreal Engine shows just normal which fits with it running again after reconnecting monitor.