If you click the combobox button (rather than choosing an option) when it is open, it will close but the next click will not properly open the options again, instead they tend to appear for a frame and then disappear. Two clicks is needed to open the options, instead of just one.
Create a combobox with some default options.
First click opens the options.
Second click closes the options.
Third click should open the options, but does not. (options often appear for just a moment).
I was unable to reproduce your issue on our end with the repro steps provided, I have a couple of questions about your issue to help me narrow down the issue you are experiencing.
Are you able to reproduce this issue in a new project?
for your combo box, do you have something coded or scripted when the value is changed?
Could you provide screenshots or video of your issue?