UI Buttons not clickable when in fullscreen mode in packaged build

Has anyone else had issues in their packaged builds with UI buttons not being clickable when in fullscreen mode?

I’ve had a number of people report they can’t push UI buttons when in fullscreen mode, but after changing to windowed fullscreen mode or windowed mode they are able to click the buttons.

I know I’ve seen issue with stretching and box hit collision in UIs with other UE based games (specifically, Hell Let Loose and Squad) when using fullscreen mode in a non-native resolution, which I’d guess is related to the same issue… I wonder if there is some setting that isn’t being set correctly which is causing this issue or something.