Uefy 2.0 (Pro Edition) make Blender's rigify rigs compatible with UE5, also has a FREE version

Yes you can use the script with a static mesh with no skeleton. I’ve been meaning to make a demonstration of this but i suck at weight painting and doing this requires getting some weight paint in there. Perhaps I can demo this with a simpler mesh just to show how to do it and leave the more advanced characters to the experts.

The process would be to add a custom armature and match the basic Epic Skeleton:

  1. Six bone spine
  2. Four bone limbs (thigh, lowerleg, foot, toe) and (shoulder, upperarm, lowerarm, hand)
  3. Three bone fingers.

Then you need to rename the bones to have the same names as they do in the epic skeleton. If you make only the left side you can use Symmetrize to autobuild and autorename the other half of the skeleton.

Then comes the part I find difficult. You need to weight paint these bones. You can ignore any twist bone or IK or any of that stuff as the script will build those for you. You can update weights for those bones later.

After that just follow the rig any character video as above and it is just the same process.