UE5 crashes when simply clicking on drop down menus.

Hey there @Tim_Flinn! Welcome back to the community! So this issue happens frequently when something is interfering (or trying to help) the GPU handle something. In your case, I seeGTIII_OSD64 less commonly as a third party touching GPU memory. This is likely related to the Asus GPU tweaker, referenced in this thread:

You may just need to disable that and let me know!