I cannot update anything about a subsurface material using a subsurface profile other than the base color.
Im able to use a regular subsurface material, however, I dont have the control I need for what Im trying to do.
EDIT: I also found out when I close the material instance editor, it automatically unchecks override Subsurface Profile
Also, as a side note, my camera is randomly changing speed while I was messing with the subsurface profile. not sure if this is a known bug, but Ive been noticing it since Ive updated.