Late to the party on this but this is still broken (Disabling MPO is pretty feelsbad)
(I am running the 466.27 driver, latest as of 2021-05-17)
Feedback thread for anyone interested: https://www.nvidia.com/en-us/geforce/forums/game-ready-drivers/13/425911/geforce-46109-game-ready-driver-feedback-thread-re/2981689/