After 4 months of frustration, I have finally found a solution to this issue that does not involve rolling back the drivers.
Nvidia drivers from 461.09 onwards introduced a new feature called Multiplane Overlays, which apparently has some issues. The temporary solution for this is provided on this
Nvidia page
Running the mpo_disable.reg file will disable multiplane overlays on your system, which seems to fix the numerous issues I have had with UE and Chrome. There’s also a mpo_restore.reg to re-enable the multiplane overlays later.