Nanite in VR? 5.1? 5.2?

You should also consider the performance of your application. When are you going to release it and what is the target market/hardware? For VR you want to hit 90fps. With Nanite you also will have to use Lumen for lighting. You also don’t want to use any upscaling (no TSR or DLSS) as that will introduce ghosting and that is something you don’t want to see in VR. It might take another generation or 2 of graphics cards before hardware is fast enough to get 90FPS with nanite for the resolutions required for VR.