Is there any consequence to making reliable RPC calls from Event Blueprint Update Animation?

Our team has a basic 3rd person character set up and we are testing various things in multiplayer. Inside our animation blueprint event graph we change variables through reliable RPC calls to the listenserver to keep everything in sync. We have noticed some flickering of the client when simple running around, on the listenserver.

Could this be from making reliable RPC calls from Event Blueprint Update Animation?