Having the same issue, haven’t been able to debug anything from 4.5. XCode is trying to debug the app without the content. It’s most likely looking for a pak file. All non-editor builds require pak files.
On my build from months and months ago, I used to be able to click Run in xcode and it would just run the app already deployed on my device. Now when I click Run it copies a new app to the device and runs it. The copy doesn’t have a pak file so it gets to the ICU data directory assert and stops.