Hey there @Actuss! While I don’t believe the editor itself has direct culling enabled except when you preview game view (by pressing G in viewport). However it’s recommended for large projects to use either world partition’s level streaming system or data layers to load only the area that you’re working on in editor at the time. You can see this workflow in action in the Lyra example project.
Here’s also a worldbuilding guide that goes over some of what I mentioned:
https://dev.epicgames.com/community/learning/knowledge-base/r6wl/unreal-engine-world-building-guide