This disables all the work we did to fix circular dependency issues that arise between blueprints. So you have to be careful not to introduce cyclic dependencies (or your assets could crash on load). This is not a setting that you want to leave off long term.
The good news is that we’ve resolved your issue with https://github.com/EpicGames/UnrealEngine/commit/4b7defc1a872d82dcaf38898c60a8b0f9a726454, and should be available in a later release.
Thanks for working with us to narrow down the issue!