This seems to have come up in the past without a definitive answer. My animation blueprint is repeatedly corrupted for no obvious reason. If I rebuild the entire project in C++, it will load fine, but it will again fail the next time I launch the engine. Rebuilding and launching from Visual Studio will give me a fully functional animation BP, so there’s nothing I can see clearly wrong with the existing BP.
Are you not launching the project from VS the next time though? 
You should be doing that if it has C++ dependencies.
That I didn’t know. I presumed I could open it from the Epic launcher if it was built.
It’s hard to replicate the issue, there might be other things to consider. However, I also remember directly opening up the .uproject file was causing my assets with C++ class parents to be corrupted under specific circumstances. Regardless, you should get used used to launching projects via VS if you’re working with C++, since it’s the better practice.
I wanna add that in case you encounter an actual corruption, rather than rebuilding the project, regenerating the project files would fix the common issues.
Hope these help! 
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very helpful. will make that my standard practice. Thanks again.