Why doesn't 'E' function in the same way as 'I' on my input menu?

If I had to guess, I’d say E key is used elsewhere in some other blueprint and it consumes the input.

I’m creating a new project with an inventory system that destroys an actor in the scene when the player steps over it and presses the ‘PickupItem’ input, which I originally had set to the ‘I’ key, however every time I set it up with these inputs corresponding to the ‘E’ key the entire event doesn’t work, I encountered this problem earlier when trying to set up an interact command, with me eventually caving and setting up every interaction with the ‘E’ key rather than a custom interact input, however with this being the second time I’ve encountered the issue I’d like to know why these scripts work for Interact/PickupItem when the input is assigned to literally any key on my keyboard besides ‘E’