Which License do I choose if I'm doing a variety of project types?

In short, I plan to sell some small games (Publishing License) as well as develop free, internal, linear, and custom applications/content (Creators License). It sounds like you can only stick with one at a time, although I am unsure why. I currently have Publishing License. Do I need to switch between them based on the project, is there a difference, does it matter? Thanks!