The non-simple skeletal mesh contains extra bones that are used by the ABP_Manny_PostProcess Animation Blueprint to give better deformations as certain bones move. If you have seen the “candy-wrapper” wrist, that’s the kind of thing it’s used to fix.
Why epic seems to have removed it is beyond me.
UPDATE:
The way this is now being done is using the simple skeleton and driving additional deformations on the twist bones with generic bipedal pose assets rather than mesh-specific pose assets. For more info, check out how echo is done in the Animation Sample.