Hey,
completely depends on how and what you use.
I.e. if you use a tree pack from the marketplace, noone will really notice. Characters are another story and if the same characters are used in various games this will be very noticable.
Also, you can be very creative in using the assets. Does a doorway always need to be a doorway, or can it be used as something completely different (scaled and rotated)?
Despite what “professionals” will say, there is no problem with using marketplace assets in commercial games. Some people will recognize it, but if your game is good enough, most people wont care. A good example for that is QuiVR (Unity engine though) which used asset store characters, props and architecture. Noone really cared, because the game was good enough. (Though QuiVR changed to its own assets created by the team after they got in enough money from alpha sales).
Cheers,