This problem was plaguing me as well. After hitting “apply” in Persona it worked correctly for me. If “apply” is grayed out just re-key part of the animation and it will light up. Hope this helps.
I also encountered this problem and it nearly took me 2 days to figure it out.
In my case I needed to set the “retargeting options” to animation instead of .
This broke some of my animations but now i can change them in Persona and it works with blend spaces.
Retargeting options can be found as described here: Using Retargeted Animations in Unreal Engine | Unreal Engine 5.1 Documentation
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I encounter this bug in 4.16, and this solution works for me!
Thanks!