With the below graph in an “OnMouseMove” override in a widget, I expect all the instances of the instanced static mesh in BP_Boxes to have their transform updated when I drag the mouse. But nothing happens, then transforms don’t update at all.
I should add that I can trigger other stuff on this widget when I click and drag the mouse, just not this. I am guessing that I am using the Update instance transform the wrong way. 
Any ideas on where I go wrong here?
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You have to true the “Mark render state dirty”.
It’s just an efficiency thing so you can update the transforms on a batch of instances then re-render the ISM once.
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Thank you! That seems to be the solution.