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I just open a new “issue” on 4.10.1 : Avast Virus on build dll (Engine & Game) - Platform & Builds - Epic Developer Community Forums
Avast antivirus is claiming to find a root kit on all Libraries buildt by UE4 since 4.10.1 (we just move from 4.9 this week end).
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Avast is causing the engine not to run on packaged games on 4.10. I know other projects are having the same issue. Closing the antivirus allows you to run, but hopefully thats not the perma-fix =)