Yep it’s definitely the multiple graphics cards. Managed to have direct mode working fine now but had to run in SLI mode with all my displays on the 1 card. Quite odd that it needs SLI mode, normally SLI is the 1 that tends to cause problems with things.
Works really well so far, few minor hassles here and there with 1 laser pointer not wanting to do the rotations or select the things in the displays but aside from that seems to work fine