Understanding Sequence Play mode vs 'Game-Blueprint' Play mode and how they interact

Development Cinematics & Media
1

As a novice there is something missing in my understanding of how Unreal is working in ‘Play’ mode.

I am creating Cinematics so everything is being driven from my Sequence(s).
I also am trying to Lerp an Actor position from my Level Blueprint with a Timeline Node and a Lerp based on a trigger event from my Sequence. My question is

Is it sufficient for me to playback my sequence and trigger an event in my Level BP for the Timeline+Lerp to work,
or do I also need to enter ‘Game Play’ mode in my Blueprint-Viewport?
And if so, how do I trigger Game Play mode from my Sequence?

2

is there a reason you’re using a lerp and not just keyframing the actor position?
when you record, it’s always using game play mode