Considerig your crash log, it seems the conflict comes from a clash between the neural components of UE and your PC, as you got calls to “UnrealEditor-NNERuntimeORT.dll” and “npu_d3d12_umd.dll” respectively. When you launch the engine, the NNE component tris to reach D3D12, goes through the NPU driver, and the whole thing crashes.
Checking around the community, there are a few methods to fix this kind of scenario, let’s cover them one by one:
First, the most simple approach, if this is happening with a specific project, in which you don’t need to use neural network features, then you can disable the plugin for said project. That can be done from the Plugins sub-menu, but since UE is crashing on opening, it should be done externally. Navigate to your project’s main directory, and look for the .uproject file. Open it with a Notepad, and look for the Plugins section, it should be listed as “NNERuntimeORT”. There, just change the “Enabled” value to false, save the file, and test your project again.
Now, if this is happening even with empty projects, then we need a global fix. And that would be disabling the NPU feature in your system. To do that, in Windows, open the Device Manager, and look for “Neural processors” (it should have it’s own category, or inside “System devices”). There, look for the NPU device (which depending on your CPU, should be “Intel(R) AI Boost” or “AMD IPU Device”), right-click on it, and pick “Disable device”. Apply the change, restart your PC if required, then test UE one more time.
If the issue still remains active, then it could be related to GPU as well. For that, the approach is simple: Update your current set of drivers to the latest version available (you can also use DDU for a clean install), and test UE with DX11, which can be forced by adding the -d3d11 tag to its shortcut.