Hi! Yes, it would be possible if you will scale your UI covering whole area of all your screens (like it’s a one big screen), and then using nDisplay get the node id you are using, to apply UI offset. Offsets can be calculated kind like that:
{Offset} = {ScreenPosOnLayout}[ScreenID].xy*{UIScale} - {ScreenDisplayAreaDimensions}[ScreenID].xy
Also it may be more comfortable to use grid in your UMG editor to perfectly align your displays.
Ps. or u can make separate UI for every screen, but it would require more design accuracy and i think 