RTX 3080, Ryzen 9-3950X, UE5 @ 9ffd17e here to report the same issue. It’s sometimes not instant, and I can usually load the affected level in the editor and zoom around for a while, but I always get some variation of the same message: D3D device lost, reason hang. Interestingly, enabling RTX seemed to offset the issue for a minute or two in some cases.
Sometimes it is just an engine crash with a crash report dialog, others it’s a black screen requiring Win+Ctrl+Shift+B, others that doesn’t even work.
I’ve more or less eliminated an actual hardware fault. Voltage across all lines is consistent under much higher load in other games. In fact, the only game I’ve recently had issues similar to this with is Fortnite.