I had the SM6-related crash on 6800xt too. Updating the driver to 22.11.1 resolved the issue for me (windows 10). Note that nanite no longer functions without SM6, nanite enabled meshes will revert to fallback meshes with SM5.
I’m seeing a virtual texture-related assignment editor freeze issue but otherwise everything is working (might be a localized issue due to some aspect of my project and/or system since I’m not seeing any other similar reports yet.)
Edit* Turns out the editor freeze issue I’m seeing is directly related to adding a second RVT volume to the level. Otherwise, 5.1 has been pretty solid so far.