This video goes over how to use the new Auto Retargeting that has been released in Unreal Engine in 5.4 for Bipedal Characters. This goes through a step by step guide of what happens under the hood, what skeletons are supported, and how this can help with your retarget workflows.
https://dev.epicgames.com/community/learning/tutorials/GpL9/unreal-engine-fortnite-auto-retargeting-for-bipeds
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Thank for adding that section on Vicon! That flipped Mesh was getting on my nerves. Maybe one day Vicon will fix the default pose.