I’m having the same condition. I think substrate set certain setting by itself according to the node we place and plug in. In my case I was following this tutorial on Substrate, and I noticed that the root node had ‘opaque’ and ‘default lit’ (19:29) in the details panel, and when values for SSS MFP and SSS Anisotropy were plugged in, I noticed it had changed to ‘Opaque’ and ‘Subsurface profile’. (21:15) I’m still not sure greying it out is desired behavior.