Can you run UE4?
If so your off to the races.
As advice, and not to suggest that you listen to me at all, all things development wise must be accomplished through discovery and not based on opinion be it right or wrong.
Your question is relevant as this is where everyone starts out as in if I turn the key will the car start?
The answer, ignoring any idea of best practice, is yes as long as you can get UE4 to run and everything else is figuring out what you need when you need it and everything else is about trade off’s.
If you wait until someone tells you it’s OK then it’s to late. 