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Settings in the editor breaks games from Steam and EGS

Why settings in the engine affect games purchased in Steam and EGS? Game on UE4.
For a long time I could not run games:
Astroneer(Steam)
Outriders (Steam)
Remnant: From the Ashes(EGS)
Core(EGS)
This game crashes from launch.
And fix this in I Turn off setting “Force all skinned meshes to recompute tangents(also forces Compute SkinCashe)”.
I need download Engine Version (4.23) for Astroneer and Turn off this setting, and Astroneer not crashes from launch. And for each game you need to download your version of the engine.
Why are the settings in the editor affect the games?
Setting

Windows 10 21H1, i5 10600K, GPU RTX 2070S, RAM 32Gb.