Thanks for the info @RobMeade! Yes I think it would be a good idea to try and find some similarities between our setups. The issue also happens on all projects for me. I haven’t been using Unreal for long, so I suspect my setup was always prone to the defect. I’m running from a laptop (rtx 2060) that’s connected to an ultra-wide monitor (2560x1080). I disable the laptop screen and only use the monitor. The next time this happens, I’ll try some of the workarounds you suggest.
Edit: I just hit the issue again. When I move the editor back to the laptop screen it works fine. I also get black screen flashes in MS Edge just like @shubyyy_yg