Question: Mixing 2D tilemap and 3D scene

Hi all,

I want to make a game where as there is 2D isometric top down environment to explore and it transition to 3D first person when battle. Previously I tried it out on Unity engine and it turns out it is difficult for me to fiddle around with the lighting engine(cant render 3D lighting when 2D lighting is used).

I did some research regarding UE4 having Paper 2D to create tilemap but I am not sure how does UE4 works along with 2D lighting.

Can unreal engine handle both 2D scene and 3D scene within a project?