"Priming" UE4

Is there a way one could generally “prime” for lack of better words for UE4. Like basically change the computer from general work mode, to what would be UE4 Mode. This way functions and processing power can be completely focused on UE4. I have a very high-end computer, but I receive some lag when I run on Editor Mode on all three of my monitors. Play Mode does not lag to clarify. Thanks for your help!