"Play as Client" PIE not working correctly

Clients not connecting. Doing open 127.0.0.1 also results in the client just loading the “Game Default Map”.

Did find this in the log, however:

[2021.04.01-18.40.11:733][758]LogNet: UIpConnection::HandleSocketSendResult: Socket->SendTo failed with error 21 (SE_EADDRNOTAVAIL). [UNetConnection] RemoteAddr: 127.0.0.1:17777, Name: IpConnection_0, Driver: PendingNetDriver IpNetDriver_1, IsServer: NO, PC: NULL, Owner: NULL, UniqueId: INVALID Connection beginning close timeout (Timeout = 0).

I did switch back to Malwarebytes during the period of time when this stopped working, but adding exceptions and closing Malwarebytes completely did not help at all.