Hi Gamixie,
You are not at a pixel multiple of the size of your sprite. To get ‘pixel-perfect’ sprites you need to move your camera in or out (perspective) or adjust the ortho width (orthographic) until you end up at a nice multiple. For example, say you want to have a 320 ‘pixel’ screen but the actual screen width is 1920, then you need to be back so that each ‘pixel’ is really 6 pixels on the screen. If you’re not exactly on a multiple, you’ll see some source pixels being larger than others (e.g., if you’re at 4.5, then some pixels will map to 4 destination pixels while others map to 5).
Cheers,
Noland