Mixamo Animation Retargeting

With 4.16 you should not have this sort of problem, the preview mesh should be already ok. Could you double-check to have followed all the instructions reported in the documentation video: ? In particular that you set the rig of the Unreal Engine 4 mannequin skeleton to the “Humanoid” rig set. This is used by Unreal Engine to detect “compatible” skeletons during retargeting.