Menu Buttons not being clickable on certain Computers

I have a basic menu screen on a project with the standard options of play, quit etc.

The buttons change colours on the different states and all woks fine in the editor.

When the game is packaged, it runs on a MacBook pro fine with the menu buttons working as specified and are clickable. So this suggest that basics things like hit-test and z-order are correct.

However, when the exact same project is run on a iMac with a retina display, the project opens fine, the menu is displayed but NONE of the buttons can be clicked.

From the research I have done there seems to be an issue with how the interface is scaled on different screen sizes. However, I am at a loss as how to fix it.

Any help or advice on this issue would be appreciated.