Not sure what is going on here, the metahuman skin material instance works fine in UE4, but migrating to UE5 causes it to break. I am no longer able to adjust skin parameters in the instance. It changes in the material viewer but not the actual game viewport for some reason.
Nevermind! I found out that the skin materials have LOD materials. And they are referencing a base instance and the settings I was trying to adjust were on the Material LOD 0 but it wasnt visible in the viewport.