Material Instance Engine Startup Error

Seems like it’s pointing towards a shader cache generation function
void UMaterialInstance::CacheShadersForResources(...parameters ....){ ...... }
it crashes on a PostLoadCheck.

Maybe your shaders are corrupted / damaged or there is a problem during their generation.
Do you have enough disk space and ram to run your project?

Perhaps you added a lot more levels and now the system can’t handle the generation of extra shader data for some reason? (maybe disk space or too low page file, too little ram).
Did you add any large virtual shaders to your project?

You would try deleting DerivedDataCache and regenerating the shaders if something went wrong with them.