Is there a way to implement damage from a part of a sprite or do my weapons have to be seperate sprites?

Okay, that sounds simple enough. I will try to figure hat out when I get home. The problem is it would only be doing damage during 2 of my frames and the only way I know to do any thing where I can visibly see the those frames is in the flipbook editor. Should I 're-animate it with the timeline or can I open a blueprint using that flipbook?