I have spent a lot of time on this (and similar issues), and basically, the best way to think about UE is that sequencer is an entirely different piece of software, where the game-engine is… well, not that useful. It can be useful for some things (like enabling/disabling niagara events etc.), but you have to keep your animations separate - in sequencer, use transforms and animations, in game-engine, use BPs.
What I’d really love to see though is how people can animate large scenes in sequencer, with many different objects moving etc. I can’t imagine how would one person do that (team via sub-sequences yes, but otherwise?).
–smm