How to put external footage and Arduino interaction in sequencer at once?

I’m trying to make interactive media art with UE5.
I want to put an external video in a sequencer and then connect Arduino to switch with my unreal scenes by user interaction.
I’ve seen some references about simple arduino interaction, but I haven’t found any references about arduino interaction with ‘external video’ in ‘sequencer’

Is there a way to do this, or is it better to come up with another alternative?