How to Manipulate Bones in the Animation Blueprint?

I’m trying to use the Fabrik node to attach left hand to the players weapon. But nothing happens and I can move the bones at all, Ive also tried the two bone ik node and I get the same results. I noticed it says “bone manipulation disabled in this mode” and I’m not entirely sure what that means… any tips would be great. Thanks!!

Ive also tried in 4.22 and 4.21 and cant seem to figure it out.

I guess you Just need to Compiler the Graph. Can you Share a Screenshot of your Setup?