How to make an object glow in Unreal Engine 5?

Indeed this will be only indirect lighting (and as so achieve “correct interaction with Lumen”, which is the GI solution), but direct shadows will not be that good.

I don’t think it is possible to have an emissive material that cast direct shadows. What I’d test to approximate such effect is to use 6 rect lights located at the bounding box of the geometry. I think the result would be quite OK.